I've had the incredible 2 about 18 months with no problems; I just took it out of my pocket to make a call, and the screens have all reset to factory - my 5 screens of icons are gone and I have the Welcome to HTC Mail message. All the apps I've downloaded are still available, but this is a pain. Is there any explanation?
Personally, it takes me hours to setup my phone the way I want it after a reset so I understand your frustration! Has the device been functioning as normal since this occured? Had you recently installed any new applications before this happened? Did you notice any new updates coming through to the phone? I would be more than happy to provide additional support if needed.